Everything about 21-hydroxylase totally explained
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Steroid 21-hydroxylase (or
steroid 21-monooxygenase or
21α-Hydroxylase; ) is a
cytochrome P450 enzyme which is involved with the
biosynthesis of the
steroid hormones
aldosterone and
cortisol.
The
CAS number is 9029-68-9.
21-Hydroxylase is encoded by the
gene CYP21B.
Reaction
It
catalyses the
hydroxylation of the
carbon atom 21 in
steroids (adding an "–OH"), which is necessary with the formation of these
hormones.
Image:Progesterone-2D-skeletal.png|Progesterone
Image:Deoxycorticosterone.svg|11-deoxycorticosterone
Image:Steroid-nomenclature.png|Steroid numbering - #21 is near center top
Pathway
Clinical significance
A
defect within the CYP21B gene causes a disturbance of the development of the enzyme, which leads to
congenital adrenal hyperplasia due to 21-hydroxylase deficiency. A related
pseudogene is located near this gene;
gene conversion events involving the functional gene and the pseudogene are thought account for many cases of steroid 21-hydroxylase deficiency.
Further Information
Get more info on '21-hydroxylase'.
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